It depends what you are using to run your JavaScript. If you are running JavaScript on the server (using SSJS or a JavsScript JSP, for example) then you have access to all the usual Java resources and can run or communicate with applications on the server. If you are running JavaScript in a browser you are limited in many ways by the browser capabilities and the Java sandbox. It should be possible to sign and trust a simple applet which will proxy your JavaScript through LiveScript to the applet and in turn to an application running on the client, but I can't imagine it will be a simple or robust process. May I ask what you need this for? We may be able to help with an alternative way of achieving what you require.